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An additional limitation is the scarcity of studies specifically addressing these questions in dogs, despite the fact that canine models represent an excellent opportunity to investigate antioxidant interventions in the context of natural aging and age-related diseases
It affects skeletal muscle (impaired glucose uptake), the liver (impaired glycogen synthesis), and paradoxically, the ovaries (which remain sensitive to insulin's androgen-stimulating effects)
Patel emphasizes the importance of personalized healthcare
Immune reprogramming is also systemic, as shown by reduced cytotoxic immunity and increased immunosuppression in pre-metastatic lungs and distant metastatic sites (179181)
