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The mechanisms of DTP cells formation are not universal to all types of cancers, cancer type and drug specific mechanisms were reported in different model systems, highlighting the complex nature of this phenomenon

85 Mechanistically, glutaminolysis can be activated by TGF-, which further facilitates the generation of extracellular matrix (ECM) generation, such as collagen

[PMC free article: PMC3171935] [PubMed: 21804091] 899

Noshahr ZS, et al