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Headline points: Both compounds independently produce dose-related nausea, vomiting, constipation, and decreased appetite

Most importantly, vitamin B12 methylcobalamin is the specific form of B12 needed for nervous system health

doi:10.1016/s1383-5742(00)00050-8

Both NAPQI and ROS cause mitochondrial DNA damage, activation of the JNK signaling pathway, which further amplifies the mitochondrial ROS production, and causes the mitochondrial permeability transition (MPT) pore to open (Iorga et al., 2017)
