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[243] [245] Because of its behavior as a prodrug and its pharmacokinetic differences, lisdexamfetamine has a longer duration of therapeutic effect than immediate-release dextroamphetamine and shows reduced misuse potential

The carnitine shuttle offers a means to transport two carbon units to the cytosol without concomitant oxaloacetate production and thus one prediction is that this route might be important for supporting histone acetylation or lipogenesis in cell types that do not engage the non-canonical cycle

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Results Among 218 patients with available TMAO measurements, those in higher quartiles showed an increased all-cause mortality compared to the lowest quartile after 180 days (adjusted HR 1.92 95% CI 1.033.56, p = 0.04) and 5 years (adjusted HR 2.01 95% CI 1.233.31, p = 0.006)