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Description
PfB and BruB were shown to catalyze regioselective and stereoselective electrocyclization of polyene products from the respective PKS-NRPS, followed by either a [4+2] cycloaddition to give ()-PF-1018 ( 285 ), or [3,3]-Cope rearrangement to give 286 , respectively (Figure 62)
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Pregnant individuals or those with existing health conditions should speak with a medical professional to determine whether IV therapy is appropriate for their situation
