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retroviruses such as the lentivirus are suitable tools to achieve long-term gene transfer since they allow long-term, stable integration of a transgene and its propagation in daughter cells

In this five-year update of the ECHELON-2 trial, the frontline treatment of patients with PTCL using A + CHP continues to provide clinically meaningful improvements in PFS and OS compared to CHOP, with a manageable safety profile, including the continued resolution or improvement of peripheral neuropathy [226]

10.7150/ijbs.87975 63 LiuY.-S.YuanM.-H.ZhangC.-Y.LiuH.-M.LiuJ.-R.WeiA.-L.et al (2021b)

Importantly, the Fenton reaction based on the release of Mn ions and the inactivation of GPX4 accompanied by accumulation of lipid peroxidation and ROS that can further sensitize Cuproptosis [173,174,175]