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They're the long-established standard of care, both FDA-approved, both backed by decades of clinical data

A common way to supplement a diet with vitamin B12 is through injections

Samples were injected automatically and separated on an analytical column Acclaim RSLC PA2, 250 2.1 mm, 2.2 m (Thermo Scientific, 074814)

If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required
