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Experimental toxicology studies in several animal species however show that these metals cause a decrease in the level of the measured thiols in the target tissues of the treated organisms [11] and generate oxidative stress, as measured by the several currently employed biomarkers

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PD is a multifactorial neurodegenerative disorder with complex pathophysiological changes that extend beyond dopaminergic dysfunction

Specifically, E-cadherin expression was enhanced, while N-cadherin, Vimentin, and Snail expressions were reduced, and inflammation markers were also decreased (Figure 2A, B, and E)