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Administrated resveratrol positively affects the synthesis of sirtuins, SIRT1 (a family of proteins NAD + -dependent histone deacetylases playing an important role in the regulation of metabolic pathways, see below) activating then superoxide dismutase 2 (Mn-SOD) expression in cardiomyocytes and improved cardiac functions (Tanno et al

That changed with two landmark trials

Nrgaard, P

1-MNA, a product inhibitor of NNMT exhibited no passive permeability (Table 4)