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doi: 10.3390/ijms26030944 162 ChavezJDTangXCampbellMDReyesGKramerPAStuppardRet al

PDK2 is the most sensitive to inhibition by pyruvate, whereas, PDK4 is relatively insensitive
There are many compounds that regulate Adk, including mycophenolic acid (MPA)

If a deficiency is identified, intravenous carnitine supplementation can be beneficial
