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The production of intrinsic factor happens in the stomach, which if impaired, can have a hard time properly synthesizing this protein

See: Statistics from Altmetric.com COMPLEMENTARY MEDICINE PAIN MANAGEMENT QUALITATIVE RESEARCH STATISTICS & RESEARCH METHODS Clinical trials Strengths and limitations of this study The study design is a randomised, placebo-controlled, single-blind clinical trial using parallel groups

[1] Some compounders suggest adding B12 to tirzepatide formulations based on theoretical concerns about vitamin B12 absorption, though it's important to note that clinical evidence specifically linking tirzepatide to B12 deficiency is lacking

Factors That Determine How Often You Should Have B12 Shots Several factors influence how often youll need B12 injections, including: 1