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doi: 10.1152/japplfisiol.01011.2006

Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice

In this model of transient insomnia, a single 6 mg dose of doxepin given to healthy volunteers was well tolerated and resulted in significant improvements in PSG-defined and patient-reported sleep onset, maintenance, and duration endpoints that lasted into the last hour (hour 8) of the night

While robust clinical trial data specific to these combinations continues to emerge, the physiological rationale and supporting evidence from component studies provide a sound basis for clinical application in appropriately selected patients