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Description
For the adrenal cortex, inhibition of CBS/CSE can result in mitochondrial oxidative stress and dysfunction, while corticosterone response to the adrenocorticotropic hormone is weakened, which is reversed by morpholin-4-ium-methoxyphenyl-morpholino- phosphinodithioate (GYY4137, an H 2 S donor)

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Siegwart K

Cell 166 , 907919 (2016)

Its mechanism of action, dosing convenience, and synergy with semaglutide place it at the forefront of next-generation obesity pharmacotherapy
