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In systemic lupus erythematosus (SLE) pregnancy, neutrophil extracellular traps (NETs) promote glycolysis and lactate production in trophoblasts, leading to NLRP3 lactylation, which subsequently activates the inflammasome and triggers pyroptosis (132)

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Parallel cellular-level investigations utilized HK-2 cells plated in glass-bottom dishes (2 10 5 cells/dish, Nest)

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One of the major antioxidant pathways counteracting ferroptosis is System Xc - -GSH-GPX4

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