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& Veldhuis, J
Fe + catalyze the formation of OH from H 2 O 2 , further reducing GSH levels, lowering GPX4 activity, promoting lipid peroxide accumulation in tumor cells, and initiating ferroptosis
However, the side effects are not predictable and anyone can suffer at any time, while some people may not face any problems at all
Clinically, such insights may pave the way for combination strategies, for example pairing JAK inhibitors with modulators of innate immune activation, thereby improving long-term repigmentation stability
