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I have gotten the shingles vaccine, also MMR & Tdap boosters without serious side effects (except for a frozen arm for 1 week after the Tdap), but I once had a long term reaction to a flu vaccine which caused shortness of breath for many months

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(Qiu et al., 2023) reported low levels of NAD + in the aorta from hypertensive patients showing that supplementation with NAD + precursors effectively lowered blood pressure and improved impaired vascular function in both hypertensive patients and mice

However, prolonged use can weaken shoulder muscles due to underuse