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Description
Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H, et al

The peptide mimetic DPP-4 inhibitors including vildagliptin, saxagliptin and teneligliptin, were identified by peptide-based substrate substitution experiments, while the non-peptide mimetic group such as sitagliptin, alogliptin and linagliptin, were derived from the inhibitor and initially found in random screening

As such, any clinical use should be framed as exploratory and hypothesis generating rather than standard of care

Below, we discuss some of the potential effects