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Tirzepatide (e.g., Mounjaro) Mechanism: Tirzepatide is a dual agonist that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), offering a two-pronged approach to appetite suppression and insulin regulation

Abbreviations BBB Bloodbrain barrier CFS Chronic fatigue syndrome CNS Central nervous system CoA Coenzyme A COVID-19 Coronavirus disease 2019 CrAT Carnitine acetyltransferase CRP C-reactive protein HPA Hypothalamicpituitaryadrenal IDO Indoleamine 2,3-dioxygenase IL-2 Interleukin-2 IMD Immunometabolic depression MDD Major depressive disorder ME Myalgic encephalomyelitis mGluR2 Metabotropic glutamate receptor 2 MS Multiple sclerosis NMDA N -Methyl-d-aspartate NMR Nuclear magnetic resonance Nrf2 Nuclear factor erythroid 2-related factor 2 OCTN2 Organic cation novel type 2 transporter OCT1 Organic cation transporter 1 PAIS Post-acute infection syndromes PASC Post-acute sequelae of SARS-CoV-2 infection PDC Pyruvate dehydrogenase complex PGD2S Prostaglandin D2 synthase gene QUIN Quinolinic acid ROS Reactive oxygen species Trp Tryptophan TCA Tricarboxylic acid HO-1 Heme oxygenase 1 PUFAs Polyunsaturated fatty acids CACT Carnitine-acylcarnitine translocase MRI Magnetic resonance imaging [ 18 F]FDG-PET/CT [ 18 F]Fluorodeoxyglucose positron emission tomography/computed tomography Author contributions Literature search: DLH, EMD, EL, LVD, LZ, AR, ZDS, BB