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Importantly, alterations in the cardiac metabolism of ketone bodies contribute to the severity of heart failure

A small, randomized, controlled clinical trial that was published in 2020 found that there was a statistically significant reduction in intense pain, sharp pain, and cold and itchy sensations in the CBD group when compared to the placebo group. However, a study published in 2023 found no significant difference in neuropathy pain relief effects between cannabis-derived medicines and a placebo

Due to the lack of optimization of well-being of the treated individuals, new ways of treatment or supplementation are being investigated

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