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128 Not much is known about its physiological role, despite the high OXM- like immunoreactivity in the CNS, particularly in the hypothalamus

In mice, daily oral administration of a high dose of ergothioneine (70 mg/kg/d) for 28 d showed that while ergothioneine primarily accumulated in liver and whole blood, levels also increased in multiple tissues including kidney and brain (Reference Tang, Cheah and Yew38)

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