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Traditional surgical, genetic and pharmacological studies have tested systemic actions of circulating androgens, and more recent transgenic approaches have allowed for tests of AR gene function in specific androgen responsive niches contributing to body composition, including: skeletal muscle and surrounding interstitial cells, white and brown adipose, as well as trabecular and cortical bone

Certain foods, particularly those high in a nutrient called choline (such as egg yolks, liver, and some types of fish), are also broken down into TMA by gut bacteria [2] [3]