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Access this article Similar content being viewed by others Abbreviations AKG: -Ketoglutarate ASCT2: Alanine, Serine, Cysteine Transporter 2 CRC: Colorectal carcinoma ccRCC: Clear cell renal cell carcinoma ER: Estrogen receptor Gln: Glutamine GS: Glutamine synthetase GLUD: Glutamate dehydrogenase GLS: Glutaminase isoenzyme GLS2: Glutaminase 2 isoenzyme GSH: Glutathione HCC: Hepatocellular carcinoma HNSCC: Head and neck squamous cell carcinoma LAT1: Large amino acid transporter mTOR: Mammalian target of rapamycin NSCLC: Non-small cell lung cancer ROS: Reactive oxygen species SNAT: Sodium-coupled neutral amino acid transporter SLC1A5: Solute-linked carrier family A1 member 5 References DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism

Influenza A virus is a notable example, in which the coordinated action of the receptor-binding protein haemagglutinin and the receptor-cleaving enzyme neuraminidase facilitates penetration of mucus while ensuring firm binding to epithelial cells once the barrier is crossed 242

Nicotinamide (B 3 ) 3 ) A small study involving 25 patients was reviewed in which patients receiving a combination of radiation and hyperthermia (increase in body temperature) saw a complete response in 72% of the patients with fewer side effects when niacinamide supplementation was implemented (2)

reduces incidence and severity of vasomotor instability episodes