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doi: 10.2147/IJGM.S45271
The mechanism involves positive regulation of the expression of ALDHs and cytoprotective enzymes (e.g
We estimated hemorrhage as a percentage of the affected brain area
These therapies display higher efficiency compared to classical senolytic drugs (BCL-2 or tyrosine kinase inhibitors) but for some of them, such as NA + /K + ATPase inhibitors, clinical development could be complex in the light of strong cardiotoxicity associated with this class of molecules
