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Recognizing the pathological impact of these multifaceted interactions provides a compelling rationale for therapeutically targeting this axis to reprogram anti-tumor immunitya strategy explored in the next section
For several decades, experimental evidence has supported two theories for aging
This is perhaps one example of the age-onset rewiring of the diurnal regulatory network
Genetic disorders and mutations in UGT1A1 bring about syndromes like Gilberts syndrome or Crigler-Najjar syndrome, each characterized by decreased bilirubin conjugation [29]
