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When melanocytes are hyperactivated by specific triggers UV radiation, post-inflammatory signals from acne or injury, hormonal changes (especially estrogen and progesterone in melasma), or genetic predisposition they produce excess melanin that accumulates in patches, creating dark spots, uneven tone and visible discolouration

[DOI] [PubMed] [Google Scholar] 29.Jeulin C., Lewin L

The HSC immunophenotype is complex and not fully understood, so identifying novel markers, such as CD35 or CD11a [131], may present new targets

Mechanical stress can damage the tripeptide (although as a smaller molecule its mechanical sensitivity is lower than that of large peptides)