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These mouse studies appear relevant to human disease, as a large number of studies have shown that polymorphisms in PON1 are associated with increased risk for atherosclerosis (265)
Secondary deficiencies can arise from various conditions, including chronic kidney disease, hemodialysis, certain genetic metabolic disorders, and the use of specific medications like valproic acid
Randomized trials have demonstrated that omega-3 supplementation improves sperm morphology and DHA content in sperm membranes
