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Interestingly, loss of endothelial GS expression or pharmacological blockade of GS also retards EC migration, but not proliferation, and angiogenesis in pathological mouse models, while only minimally affecting healthy adult quiescent ECs
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By modifying gene expression without changing the underlying DNA sequence, this process predominantly occurs in CpG islands, regions where cytosine is positioned next to guanine [147]
Crizotinib, a MET inhibitor, prevents peritoneal dissemination in pancreatic cancer
