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Degeneration of RGCs and loss of their axons, as well as damage and remodeling of the lamina cribrosa constitute the main events in the pathogenesis of glaucoma ( Different molecular pathways are involved in RGCs death, which are triggered and exacerbated as a consequence of a number of risk factors such as elevated IOP (Nouri-Mahdavi et al., 2004), age (Leske et al., 2004

USA 94 , 4247 (1997)

Routes to molecular glue degrader discovery