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The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]
Additionally, carnitine has shown protective properties against hypertension, hyperlipidemia, hyperglycemia, diabetic ketoacidosis, insulin resistance, insulin-dependent diabetes mellitus, obesity, and other conditions that enhance cardiovascular pathology
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Biochimica et Biophysica Acta (BBA)Molecular Cell Research
