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Nature 320 : 454456 Heinecke JW, Rosen H, Suzuki LA and Chait A (1987) The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells

In our experience, fewer than 5% of patients stop tirzepatide due to palpitations, and most of those cases involved patients escalating doses faster than the recommended 4-week intervals or refusing electrolyte management

Further research has revealed that Esculin induces endoplasmic reticulum stress and promotes ferroptosis in colorectal cancer by modulating PERK through the eIF2/CHOP and Nrf2/HO- 1 cascade reactions [67]
