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(e) Recordings of electrically-evoked Ca 2+ transients and caffeine-evoked Ca 2+ release made in adult rat (ar) ventricular myocytes exposed for 1030 mins to control (CON) or 6 mM propionate (PRO)

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Although metformin was initially contraindicated in advanced HF due to the risk of lactic acidosis, recent studies have shown beneficial effects of early administration of metformin in models of HF

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