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Additionally, mechanical injuries, such as joint wear, trigger inflammatory responses in cartilage and synovium, further upregulating the expression of matrix-degrading proteins, accelerating ECM degradation, and promoting OA progression (Maldonado and Nam, 2013)
Hyperglycemia causes excessive glycation of sugars and unbound amino groups in proteins, which alters their physical and chemical characteristics (Feng et al., 2023)
The accumulation of toxic lipid peroxides in myocardium also affects cardiac function
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