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Description
When folate is insufficient or in the wrong form (synthetic folic acid), methylation stalls, SAM drops, and COMT function suffersleading to either too-fast clearance (when the system is overwhelmed) or too-slow clearance (when methylation is depleted)

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The subsequent evolution of more efficient photosystems would have led to more powerful photoreactions that could extract electrons from H 2 O, and this advance would lead, eventually, to the great oxygenation event

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