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All lines of evidence indicate that fast and slow TGR inhibitors bind different conformational states present in the TGR enzymatic cycle induced by both NADPH-dependent reduction and the concomitant destabilization of the polypeptide chain, as shown by TSA

Most virus-induced asthma attacks are related to respiratory syncytial virus (RSV) and rhinovirus (RV) infections [418], and the exact mechanisms involved in the pathogenesis of this type of asthma are described in detail by Hansbro et al