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The World Anti-Doping Agency (WADA) prohibits AOD-9604 as a non-approved substance and potential performance-enhancing agent in athletics, citing concerns about unfair advantage through lean body mass gains (if efficacious, which remains unproven)

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Cartilage & Joint Research Kwon and Park, Annals of Clinical and Laboratory Science (2015) Kwon and Park investigated the chondroprotective effects of intra-articular AOD-9604 administration in a rabbit model of osteoarthritis, with and without co-administration of hyaluronic acid