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In PD, mutations in GBA, ATP13A2, and PARK9 impair lysosomal function, leading to -synuclein accumulation and cellular toxicity ( In particular, LRRK2 mutations impair endolysosomal trafficking, contributing to -synuclein clearance failure and promoting neurodegeneration ( 3 Epidemiology and global burden of Parkinsons disease Parkinsons disease (PD) is one of the fastest-growing neurological disorders globally, driven primarily by population aging, environmental exposures, and improved longevity

Caffeine and stimulant interactions Caffeine is a powerful chronotrope and sympathomimetic

NRG-GI008: Colon adjuvant chemotherapy based on evaluation of residual disease (CIRCULATE-North America)

However, it is now discovered that antibiotics-induced hormesis can activate plant defense mechanisms and enhance environmental adaptability at biochemical, growth, physiological, and production levels 17 , aligning with the xenohormesis hypothesis described by Howitz and Sinclair 81,82