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Safety Considerations Vitamin B12 supplements are generally safe, even in high doses, because your body doesn't absorb the full amount

NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)

Patients with Leber hereditary optic neuropathy should not take methyl B12, since this disease can get worse with high methyl B12 levels

Researchers hypothesized that blocking NNMT activity could represent a novel therapeutic approach, and 5amino1mq emerged as a major outcome of this effort