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Endolysosomal cholesterol accumulation has been observed in APOE4-homozygous human induced pluripotent stem cell (iPSC)-derived astrocytes (210), implicating APOE4-induced glial cholesterol dyshomeostasis in late-onset AD pathogenesis

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After one hour of exposure to DMSO, we determined the metabolic activity of the yeast cells, the stability of the cytoplasmic membranes, and the cells ability to proliferate, expressed as survival rate (i.e

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