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Spravato was granted FDA approval with Fast Track and Breakthrough Therapy designations in March 2019 for use in treatment-resistant depression and for patients with major depressive disorder accompanied by acute suicidal ideation and behavior

[PubMed: 12181312] 107

Crucially, the presence of distinct -cyclodextrins within the polymeric network not only influenced drug payload during nanoparticle fabrication but also differentially modulated mucoadhesive properties and drug permeation behavior
