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This indicates that alterations in intestinal epithelium integrity caused by genetic or environmental factors contributes to the translocation of luminal microbes that can become immunogenic when delocalised from their GI niche (Fine et al

doi: 10.1016/j.plaphy.2010.08.016

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406 Consistently, a recent study reported ZnT10 as a methylation marker in the CRC, and the methylation epigenotype significantly correlated with KRAS and BRAF mutation in CRC
