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Description
Abstract The mitochondrion is a crucial cell organelle in reactive oxygen species (ROS) production
Clin Pharmacol Ther 100(5):464478
In this study, we engineer an AC4A-modified supramolecular albumin nanoparticle (SHC4H) to treat hypoxic tumors
Concurrently, the same pool of NADPH fuels the GPX4, thioredoxin reductase, and lipid-remodeling pathways, both neutralizing peroxides and synthesizing protective phospholipids (PUFA-OHs) to counteract ferroptosis
