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Immune system The PPP plays a key role in the immune system, impacting immune cell fate and functions, such as cytokine production and the oxidative burst

Recent studies showed that in obese/diabetic animal models, SERCA2 dysfunction is induced and cytoplasmic Ca 2+ is increased, which then activates the cytoplasmic calcium-sensitive kinase, calcium/calmodulin dependent-protein kinase II (CaMKII), and triggers ER stress 16
Nrf2 activation is key to helping them do so especially with the food they eat and the toxin they are exposed to daily

HeLa, HEK293T and HEK293 cells were cultured in Dulbeccos Modified Eagles Medium (Gibco, #11995-065, Carlsbad, CA, USA) supplemented with 10% fetal bovine serum (Gibco, #26140-079, Carlsbad, CA, USA) and 1% penicillin/streptomycin (Gibco, #15140-122, Carlsbad, CA, USA)
