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nevertheless, three factors that contribute to its development are oxidative stress, immune imbalance, and genetic variation, promoting a cascade of thyroid follicle destruction [16,17,18] (Figure 1)

Although BSO+L-PAM were not as active in the TX-MM-030h cell line (established at relapse after therapy with myeloablative L-PAM) as in other cell lines, BSO+L-PAM had a greater than additive effect and induced 3 logs of cell kill