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The potential utility of incorporating this mechanism into complex LCR/beta-globin LVs was suggested by our discovery that unwanted RNA splicing is the key determinant of LCR/beta-globin -RV instability and low titers, and that this problem could be largely corrected by the removal of undesirable splice sites [131]

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10.1016/j.cell.2004.05.008 Cell 141 RochaE

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