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Therefore, there will not be any thermodynamic push to initiate the crystal growth [21, 35]
Prodrugs of ANPs with purine bases have demonstrated potent inhibition of phosphoribosyltransferases in malaria and tuberculosis [89,90,92,143], with recent advances demonstrating excellent selectivity for the parasitic enzyme over the human homolog [144]
*Data on smoking status were missing for 2 patients in the ENTYVIO group
