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Each specimen was scored using a scale ranging from 0 to 3 (0: none, 1: mild, 2: moderate, and 3: severe) for each criterion, and a final histology score was determined (0: none, 1: mild, 2: moderate, and 3: severe)

But favorable safety and plausible mechanism don't equal clinical proof of efficacy at specific doses in specific injury types

Receptor-mediated targeting: mannose receptor-targeted nanocarriers (e.g., liposomes and polymeric nanoparticles) decorated with URAT1-specific ligands demonstrate enhanced tubular accumulation, minimizing gastrointestinal adverse effects associated with systemic drug exposure (Faustino et al., 2023)

35 The screening system includes age-appropriate questionnaires for every 2/3-month intervals