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Blood Pressure Medications Avoid combining with: High Blood pressure(hypertension) medications Herbs that lower blood pressure (e.g., hibiscus, garlic) Nitrates (used for chest pain) Sildenafil (Viagra, Revatio) Why: L-arginine can lower blood pressure, and combining it with these vasodilators may cause the blood pressure to fall too low

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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10.1016/j.cct.2019.105832 Contemp Clin Trials