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Although HGF was originally identified as a potent mitogen for hepatocytes, it has also been recognized as a member of powerful pro-angiogenic growth factors ( Hepatocyte growth factor induces DNA synthesis and proliferation of vascular endothelial cells through the activation of ERK and STAT3 (Nakagami et al., 2001)

Semax This peptide is a derivative of adrenocorticotropic hormone (ACTH) and has powerful neuroprotective and nootropic properties

Front Neurol 12

As a result, the acne bacteria could concentrate instead on using their cellular machinery to churn out more compounds to attack our face and induce inflammation in acne. Indeed, as you can see here and at 3:53 in my video , without excess B12 on the skin (with B12 shown in green), the bacteria have to make most of it on their own at the expense of porphyrins (shown in red), which can trigger acne inflammation