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2010 doi: 10.1089/hum.2010.008
It has been hypothesized that CTLA-4 inhibition with ipilimumab may act on CD4 T cells, dendritic cells, or even perhaps AML leukemia cells themselves to contribute to reversal of exhaustion in CD8 effector T cells (185, 186, 213)
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In humans, dogs, and cats, they are slow-growing persistent tumors mainly of the sacrococcygeal region, with some occurring in paraspinal and cranial regions
