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Furthermore, using transmission electron microscopy, we observed a characteristic set of changes in the mitochondria after APR-246 treatment, beginning with organelle condensation and disrupted cristae architecture, followed by gross swelling, loss of outer membrane integrity and eventual rupture (Supplementary Fig
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GFAP levels at early time points correlate with injury severity and are of prognostic value in functional outcome in TBI cases (Wang et al, 2018a)
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